Drug interactions
Romidepsin + Warfarin
Severity: Moderate
Romidepsin and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin has been associated with prolonged PT/INR in patients receiving warfarin. The effect may be unpredictable, and thrombocytopenia from romidepsin adds to bleeding risk. The label recommends extra monitoring of coagulation.
What this interaction means in plain words
Romidepsin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Not fully established; possibly through effects on warfarin metabolism or protein binding, plus romidepsin-induced thrombocytopenia.
What to do
Monitor INR frequently during romidepsin cycles and adjust warfarin dose as needed. Monitor platelet counts and watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Romidepsin with Warfarin?
MediHelp rates the interaction as moderate. Romidepsin and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin has been associated with prolonged PT/INR in patients receiving warfarin. The effect may be unpredictable, and thrombocytopenia from romidepsin adds to bleeding risk. The label recommends extra monitoring of coagulation.
How serious is the interaction between Romidepsin and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR frequently during romidepsin cycles and adjust warfarin dose as needed. Monitor platelet counts and watch for bleeding.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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