Drug interactions
Romidepsin + Zafirlukast
Severity: Moderate
Romidepsin and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin is metabolized mainly by CYP3A4, so inhibitors can increase exposure. Zafirlukast is only a weak inhibitor, but increased romidepsin toxicity such as myelosuppression, nausea and QT changes is possible.
What this interaction means in plain words
Romidepsin and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak CYP3A4 inhibition by zafirlukast may reduce romidepsin clearance.
What to do
Monitor blood counts, electrolytes and ECG during treatment. Manage toxicity with standard romidepsin dose modification.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Romidepsin with Zafirlukast?
MediHelp rates the interaction as moderate. Romidepsin and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin is metabolized mainly by CYP3A4, so inhibitors can increase exposure. Zafirlukast is only a weak inhibitor, but increased romidepsin toxicity such as myelosuppression, nausea and QT changes is possible.
How serious is the interaction between Romidepsin and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, electrolytes and ECG during treatment. Manage toxicity with standard romidepsin dose modification.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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