Drug interactions
Ropeginterferon alfa 2b + Thioridazine
Severity: Moderate
Ropeginterferon alfa 2b and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interferons can suppress hepatic cytochrome P450 activity through inflammatory cytokine effects, which may raise exposure to CYP substrates. Thioridazine has a narrow safety margin because of dose-related QT prolongation, so higher levels could be significant.
What this interaction means in plain words
Ropeginterferon alfa 2b and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytokine-mediated downregulation of CYP450 enzymes, notably CYP2D6, reducing thioridazine clearance.
What to do
Monitor for signs of thioridazine toxicity such as sedation, hypotension and palpitations, and consider ECG monitoring. Reduce the thioridazine dose if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Ropeginterferon alfa 2b with Thioridazine?
MediHelp rates the interaction as moderate. Ropeginterferon alfa 2b and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Interferons can suppress hepatic cytochrome P450 activity through inflammatory cytokine effects, which may raise exposure to CYP substrates. Thioridazine has a narrow safety margin because of dose-related QT prolongation, so higher levels could be significant.
How serious is the interaction between Ropeginterferon alfa 2b and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of thioridazine toxicity such as sedation, hypotension and palpitations, and consider ECG monitoring. Reduce the thioridazine dose if QTc lengthens.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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