Drug interactions
Rufinamide + Tolterodine
Severity: Minor
Rufinamide and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak inducer of CYP3A4 and may lower exposure to tolterodine, which is partly cleared by this enzyme. Reduced bladder-antimuscarinic effect is possible, although the clinical effect is expected to be small because the CYP2D6 pathway also contributes.
What this interaction means in plain words
Rufinamide and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rufinamide belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Weak CYP3A4 induction by rufinamide increases the metabolism of tolterodine.
What to do
No empirical dose change is needed; reassess urinary symptom control if rufinamide is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Rufinamide with Tolterodine?
MediHelp rates the interaction as minor. Rufinamide and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak inducer of CYP3A4 and may lower exposure to tolterodine, which is partly cleared by this enzyme. Reduced bladder-antimuscarinic effect is possible, although the clinical effect is expected to be small because the CYP2D6 pathway also contributes.
How serious is the interaction between Rufinamide and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; reassess urinary symptom control if rufinamide is started or stopped.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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