Drug interactions
Saccharomyces boulardii + Terbinafine
Severity: Minor
Saccharomyces boulardii and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbinafine is an antifungal and S. boulardii is a live yeast probiotic, so systemic antifungals may in theory reduce the viability and effect of the probiotic. The clinical significance is uncertain and based on theoretical grounds.
What this interaction means in plain words
Saccharomyces boulardii and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Antifungal activity of terbinafine may suppress the live yeast, though the interaction is not well established.
What to do
If a probiotic is needed during terbinafine therapy, consider a bacterial probiotic or take S. boulardii after the antifungal course ends.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Saccharomyces boulardii with Terbinafine?
MediHelp rates the interaction as minor. Saccharomyces boulardii and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Terbinafine is an antifungal and S. boulardii is a live yeast probiotic, so systemic antifungals may in theory reduce the viability and effect of the probiotic. The clinical significance is uncertain and based on theoretical grounds.
How serious is the interaction between Saccharomyces boulardii and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If a probiotic is needed during terbinafine therapy, consider a bacterial probiotic or take S. boulardii after the antifungal course ends.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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