Drug interactions
Sacubitril-valsartan + Salmeterol
Severity: Minor
Sacubitril-valsartan and Salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol can lower serum potassium through beta-2 stimulation, while valsartan tends to raise it. The net effect is unpredictable and usually small at inhaled doses.
What this interaction means in plain words
Sacubitril-valsartan and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sacubitril-valsartan belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Opposing effects on potassium: beta-2 mediated cellular uptake versus reduced renal excretion from angiotensin receptor blockade.
What to do
No routine action needed; check serum potassium if high doses are used or if the patient has renal impairment or arrhythmia risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Sacubitril-valsartan with Salmeterol?
MediHelp rates the interaction as minor. Sacubitril-valsartan and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salmeterol can lower serum potassium through beta-2 stimulation, while valsartan tends to raise it. The net effect is unpredictable and usually small at inhaled doses.
How serious is the interaction between Sacubitril-valsartan and Salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action needed; check serum potassium if high doses are used or if the patient has renal impairment or arrhythmia risk.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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