Drug interactions
Sacubitril / valsartan + Simvastatin
Severity: Minor
Sacubitril / valsartan and Simvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Simvastatin is not a recognized meaningful OATP1B1 inhibitor at clinical doses, so a relevant rise in valsartan or sacubitril is not expected. Sacubitril/valsartan labeling notes statin interactions chiefly for atorvastatin.
What this interaction means in plain words
Sacubitril / valsartan and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical competition at hepatic OATP1B1 uptake; not established as clinically significant.
What to do
No dose change is needed; routine blood pressure and renal monitoring for sacubitril/valsartan is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Sacubitril / valsartan with Simvastatin?
MediHelp rates the interaction as minor. Sacubitril / valsartan and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Simvastatin is not a recognized meaningful OATP1B1 inhibitor at clinical doses, so a relevant rise in valsartan or sacubitril is not expected. Sacubitril/valsartan labeling notes statin interactions chiefly for atorvastatin.
How serious is the interaction between Sacubitril / valsartan and Simvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; routine blood pressure and renal monitoring for sacubitril/valsartan is sufficient.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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