Drug interactions
Sacubitril / valsartan + Sulindac
Severity: Major
Sacubitril / valsartan and Sulindac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can worsen renal function in patients taking sacubitril/valsartan, especially the elderly or volume-depleted, and may raise potassium. They can also weaken the antihypertensive and heart failure benefit.
What this interaction means in plain words
Sacubitril / valsartan and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
NSAID inhibition of vasodilatory renal prostaglandins reduces glomerular perfusion on top of angiotensin receptor blockade, impairing renal function, potassium excretion and sodium handling.
What to do
Avoid regular NSAID use where possible. If needed, monitor creatinine, potassium and blood pressure and ensure adequate hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sacubitril / valsartan with Sulindac?
MediHelp rates the interaction as major. Sacubitril / valsartan and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can worsen renal function in patients taking sacubitril/valsartan, especially the elderly or volume-depleted, and may raise potassium. They can also weaken the antihypertensive and heart failure benefit.
How serious is the interaction between Sacubitril / valsartan and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible. If needed, monitor creatinine, potassium and blood pressure and ensure adequate hydration.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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