Drug interactions
Sacubitril-valsartan + Timolol
Severity: Moderate
Sacubitril-valsartan and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol, even as a beta-blocker, can add to the blood pressure lowering and bradycardic effects of sacubitril-valsartan. Beta-blockers may also modestly raise potassium, but the combination is common in heart failure and generally well tolerated.
What this interaction means in plain words
Sacubitril-valsartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sacubitril-valsartan belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive hypotensive effects; beta-blockade can slightly impair cellular potassium uptake while valsartan reduces potassium excretion.
What to do
Monitor blood pressure, heart rate and potassium when starting or titrating either drug. Titrate doses gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Sacubitril-valsartan with Timolol?
MediHelp rates the interaction as moderate. Sacubitril-valsartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Timolol, even as a beta-blocker, can add to the blood pressure lowering and bradycardic effects of sacubitril-valsartan. Beta-blockers may also modestly raise potassium, but the combination is common in heart failure and generally well tolerated.
How serious is the interaction between Sacubitril-valsartan and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and potassium when starting or titrating either drug. Titrate doses gradually.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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