Drug interactions
Salbutamol + Tetrabenazine
Severity: Moderate
Salbutamol and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine causes dose-related QT prolongation, and salbutamol may add to arrhythmic risk through hypokalemia and tachycardia. The risk is greatest at high salbutamol doses or with other QT risk factors.
What this interaction means in plain words
Salbutamol and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Salbutamol belongs to Respiratory; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with beta-2 agonist induced hypokalemia.
What to do
Monitor ECG and potassium in patients with additional QT risk factors or on higher tetrabenazine doses. Use the lowest effective salbutamol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Salbutamol with Tetrabenazine?
MediHelp rates the interaction as moderate. Salbutamol and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetrabenazine causes dose-related QT prolongation, and salbutamol may add to arrhythmic risk through hypokalemia and tachycardia. The risk is greatest at high salbutamol doses or with other QT risk factors.
How serious is the interaction between Salbutamol and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium in patients with additional QT risk factors or on higher tetrabenazine doses. Use the lowest effective salbutamol dose.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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