Drug interactions
Salicylates + Sertraline
Severity: Moderate
Salicylates and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates impair platelet function and irritate the gastric mucosa, and an SSRI adds to bleeding risk. The combination increases the chance of upper gastrointestinal and other bleeding.
What this interaction means in plain words
Salicylates and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
SSRI-related platelet serotonin depletion combined with salicylate effects on platelet function and mucosal injury.
What to do
Consider gastroprotection with a proton pump inhibitor in high-risk patients. Monitor for bleeding and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Salicylates with Sertraline?
MediHelp rates the interaction as moderate. Salicylates and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates impair platelet function and irritate the gastric mucosa, and an SSRI adds to bleeding risk. The combination increases the chance of upper gastrointestinal and other bleeding.
How serious is the interaction between Salicylates and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor in high-risk patients. Monitor for bleeding and anemia.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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