Drug interactions
Salicylates + Sulindac
Severity: Moderate
Salicylates and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining sulindac with another salicylate adds gastrointestinal irritation and platelet effects, raising the risk of GI bleeding and renal effects. There is no meaningful therapeutic benefit from the combination.
What this interaction means in plain words
Salicylates and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prostaglandin inhibition leading to mucosal injury, platelet dysfunction and renal effects.
What to do
Avoid concurrent use of multiple NSAID-type agents; if used, monitor for GI bleeding and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Salicylates with Sulindac?
MediHelp rates the interaction as moderate. Salicylates and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining sulindac with another salicylate adds gastrointestinal irritation and platelet effects, raising the risk of GI bleeding and renal effects. There is no meaningful therapeutic benefit from the combination.
How serious is the interaction between Salicylates and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of multiple NSAID-type agents; if used, monitor for GI bleeding and renal function.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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