Drug interactions
Salicylates + Tolazamide
Severity: Moderate
Salicylates and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can enhance the glucose-lowering effect of tolazamide and may cause hypoglycemia, especially at high anti-inflammatory doses. The risk is greater in older patients and those with renal impairment.
What this interaction means in plain words
Salicylates and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates may displace sulfonylureas from plasma proteins and have intrinsic hypoglycemic effects at high doses; the mechanism is not fully established.
What to do
Monitor blood glucose when starting or stopping salicylates, particularly at high doses. Lower the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Salicylates with Tolazamide?
MediHelp rates the interaction as moderate. Salicylates and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates can enhance the glucose-lowering effect of tolazamide and may cause hypoglycemia, especially at high anti-inflammatory doses. The risk is greater in older patients and those with renal impairment.
How serious is the interaction between Salicylates and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping salicylates, particularly at high doses. Lower the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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