Drug interactions
Salmeterol + Spironolactone
Severity: Minor
Salmeterol and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Spironolactone retains potassium while salmeterol can lower serum potassium through cellular uptake. The effects largely counteract each other and the combination is usually well tolerated. Monitoring remains sensible in patients with renal impairment or heart failure.
What this interaction means in plain words
Salmeterol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Salmeterol belongs to Respiratory; Spironolactone belongs to Cardiovascular.
Why it happens
Opposing potassium effects: aldosterone antagonism reduces excretion while beta2 stimulation increases cellular uptake.
What to do
No routine action is needed; check serum potassium periodically in patients with renal impairment or on other potassium-altering therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Salmeterol with Spironolactone?
MediHelp rates the interaction as minor. Salmeterol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Spironolactone retains potassium while salmeterol can lower serum potassium through cellular uptake. The effects largely counteract each other and the combination is usually well tolerated. Monitoring remains sensible in patients with renal impairment or heart failure.
How serious is the interaction between Salmeterol and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check serum potassium periodically in patients with renal impairment or on other potassium-altering therapy.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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