Drug interactions
Salmeterol + Triamterene
Severity: Minor
Salmeterol and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is potassium-sparing and can raise serum potassium, while salmeterol can lower it by cellular uptake. The effects mostly offset one another, so problems are unlikely. Patients with renal impairment remain at risk of hyperkalemia from triamterene.
What this interaction means in plain words
Salmeterol and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Salmeterol belongs to Respiratory; Triamterene belongs to Cardiovascular.
Why it happens
Opposing potassium effects: reduced renal excretion via ENaC blockade versus beta2-mediated cellular uptake.
What to do
No routine action is needed; monitor serum potassium in renal impairment or with other potassium-raising drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Salmeterol with Triamterene?
MediHelp rates the interaction as minor. Salmeterol and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triamterene is potassium-sparing and can raise serum potassium, while salmeterol can lower it by cellular uptake. The effects mostly offset one another, so problems are unlikely. Patients with renal impairment remain at risk of hyperkalemia from triamterene.
How serious is the interaction between Salmeterol and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor serum potassium in renal impairment or with other potassium-raising drugs.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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