Drug interactions
Salsalate + Sulindac
Severity: Moderate
Salsalate and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate prodrug and combining it with sulindac duplicates NSAID effects. This increases the risk of gastrointestinal ulceration, bleeding and renal toxicity without added benefit.
What this interaction means in plain words
Salsalate and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cyclooxygenase inhibition causing mucosal injury, platelet dysfunction and renal effects.
What to do
Avoid combining the two; choose a single NSAID at the lowest effective dose and monitor for GI bleeding and renal function if overlap occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Salsalate with Sulindac?
MediHelp rates the interaction as moderate. Salsalate and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate prodrug and combining it with sulindac duplicates NSAID effects. This increases the risk of gastrointestinal ulceration, bleeding and renal toxicity without added benefit.
How serious is the interaction between Salsalate and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two; choose a single NSAID at the lowest effective dose and monitor for GI bleeding and renal function if overlap occurs.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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