Drug interactions
Salsalate + Tolazamide
Severity: Moderate
Salsalate and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolyzed to salicylic acid and can potentiate tolazamide, with a risk of hypoglycemia. The effect is more likely with sustained high-dose salsalate.
What this interaction means in plain words
Salsalate and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate may displace sulfonylureas from protein binding and has independent glucose-lowering activity; the interaction is not fully characterized.
What to do
Monitor blood glucose when salsalate is started, stopped or adjusted. Reduce the tolazamide dose if glucose falls too low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Salsalate with Tolazamide?
MediHelp rates the interaction as moderate. Salsalate and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is hydrolyzed to salicylic acid and can potentiate tolazamide, with a risk of hypoglycemia. The effect is more likely with sustained high-dose salsalate.
How serious is the interaction between Salsalate and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when salsalate is started, stopped or adjusted. Reduce the tolazamide dose if glucose falls too low.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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