Drug interactions
Same + Sumatriptan
Severity: Moderate
Same and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) supplements may increase serotonergic activity, and combining them with a triptan may raise the risk of serotonin syndrome. Evidence is limited to theory and isolated reports.
What this interaction means in plain words
Same and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effect through increased serotonin turnover with 5-HT1B/1D agonism.
What to do
Ask patients about SAMe use and advise caution with concurrent triptans. Monitor for tremor, agitation, sweating and diarrhea, and stop SAMe if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Same with Sumatriptan?
MediHelp rates the interaction as moderate. Same and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. S-adenosylmethionine (SAMe) supplements may increase serotonergic activity, and combining them with a triptan may raise the risk of serotonin syndrome. Evidence is limited to theory and isolated reports.
How serious is the interaction between Same and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about SAMe use and advise caution with concurrent triptans. Monitor for tremor, agitation, sweating and diarrhea, and stop SAMe if symptoms occur.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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