Drug interactions
Saquinavir + Saxagliptin-metformin
Severity: Moderate
Saquinavir and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, a boosted-protease-inhibitor component, strongly inhibits CYP3A4 and raises saxagliptin exposure, which can increase the risk of adverse effects of saxagliptin. Protease inhibitors may also worsen insulin resistance and glycemic control, partly opposing the effect of metformin.
What this interaction means in plain words
Saquinavir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition reduces saxagliptin metabolism, while protease inhibitor-associated insulin resistance pharmacodynamically opposes metformin.
What to do
Limit saxagliptin to 2.5 mg once daily during coadministration with saquinavir. Monitor blood glucose and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Saquinavir with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Saquinavir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir, a boosted-protease-inhibitor component, strongly inhibits CYP3A4 and raises saxagliptin exposure, which can increase the risk of adverse effects of saxagliptin. Protease inhibitors may also worsen insulin resistance and glycemic control, partly opposing the effect of metformin.
How serious is the interaction between Saquinavir and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg once daily during coadministration with saquinavir. Monitor blood glucose and adjust antidiabetic therapy as needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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