Drug interactions
Saquinavir + Terbinafine
Severity: Minor
Saquinavir and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir may modestly raise terbinafine concentrations. Because terbinafine is cleared by multiple pathways, the clinical effect is likely small.
What this interaction means in plain words
Saquinavir and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Saquinavir inhibits CYP3A4, one of several pathways metabolizing terbinafine.
What to do
No routine adjustment needed; monitor for terbinafine adverse effects and check liver function if symptoms of hepatotoxicity develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Saquinavir with Terbinafine?
MediHelp rates the interaction as minor. Saquinavir and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Saquinavir may modestly raise terbinafine concentrations. Because terbinafine is cleared by multiple pathways, the clinical effect is likely small.
How serious is the interaction between Saquinavir and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; monitor for terbinafine adverse effects and check liver function if symptoms of hepatotoxicity develop.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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