Drug interactions
Saquinavir + Topotecan
Severity: Major
Saquinavir and Topotecan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir inhibits P-glycoprotein and may increase topotecan exposure, especially with oral dosing. This may increase the risk of severe myelosuppression.
What this interaction means in plain words
Saquinavir and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of P-gp efflux transport by saquinavir increases topotecan absorption and reduces its clearance.
What to do
Avoid oral topotecan with saquinavir; with IV topotecan, monitor blood counts closely and adjust the dose for neutropenia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Saquinavir with Topotecan?
MediHelp rates the interaction as major. Saquinavir and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Saquinavir inhibits P-glycoprotein and may increase topotecan exposure, especially with oral dosing. This may increase the risk of severe myelosuppression.
How serious is the interaction between Saquinavir and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral topotecan with saquinavir; with IV topotecan, monitor blood counts closely and adjust the dose for neutropenia.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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