Drug interactions
Sarecycline + Tenofovir disoproxil
Severity: Minor
Sarecycline and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is a weak P-glycoprotein inhibitor in vitro and could slightly increase tenofovir disoproxil absorption. Clinically meaningful changes are unlikely given sarecycline's low systemic exposure.
What this interaction means in plain words
Sarecycline and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition leading to increased tenofovir absorption.
What to do
No dose change is needed; monitor renal function as routine for tenofovir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Sarecycline with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Sarecycline and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is a weak P-glycoprotein inhibitor in vitro and could slightly increase tenofovir disoproxil absorption. Clinically meaningful changes are unlikely given sarecycline's low systemic exposure.
How serious is the interaction between Sarecycline and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor renal function as routine for tenofovir.
What other medicines interact with Sarecycline?
MediHelp also lists interactions of Sarecycline with, for example, Acitretin, Isotretinoin, Tretinoin. The full list is on the Sarecycline page.
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