Drug interactions
Saw palmetto + Sulindac
Severity: Minor
Saw palmetto and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saw palmetto has been linked in isolated reports to bleeding and may have mild antiplatelet activity, which could add to the bleeding risk of sulindac. The evidence is weak and clinical significance is uncertain.
What this interaction means in plain words
Saw palmetto and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Saw palmetto belongs to Gastrointestinal Tract; Sulindac belongs to Musculoskeletal.
Why it happens
Possible additive effects on platelet function; the mechanism is not firmly established.
What to do
Ask patients about herbal use and monitor for unusual bruising or bleeding. Advise stopping saw palmetto if bleeding signs occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Saw palmetto
- Aspirin rectal + Saw palmetto Moderate
- Aspirin + Saw palmetto Moderate
- Dabigatran + Saw palmetto Moderate
- Desirudin + Saw palmetto Moderate
- Ketorolac + Saw palmetto Moderate
- Meclofenamate + Saw palmetto Moderate
Frequently asked questions
Can I take Saw palmetto with Sulindac?
MediHelp rates the interaction as minor. Saw palmetto and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Saw palmetto has been linked in isolated reports to bleeding and may have mild antiplatelet activity, which could add to the bleeding risk of sulindac. The evidence is weak and clinical significance is uncertain.
How serious is the interaction between Saw palmetto and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and monitor for unusual bruising or bleeding. Advise stopping saw palmetto if bleeding signs occur.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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