Drug interactions
Saxagliptin-metformin + Somatropin
Severity: Moderate
Saxagliptin-metformin and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatropin can reduce insulin sensitivity and raise blood glucose, which may weaken the effect of saxagliptin and metformin. Higher growth hormone doses carry greater effect.
What this interaction means in plain words
Saxagliptin-metformin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin-metformin belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Growth hormone induces insulin resistance and increases lipolysis and hepatic glucose output, antagonizing antidiabetic action.
What to do
Monitor blood glucose after starting or adjusting somatropin and increase antidiabetic doses if required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Saxagliptin-metformin with Somatropin?
MediHelp rates the interaction as moderate. Saxagliptin-metformin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatropin can reduce insulin sensitivity and raise blood glucose, which may weaken the effect of saxagliptin and metformin. Higher growth hormone doses carry greater effect.
How serious is the interaction between Saxagliptin-metformin and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or adjusting somatropin and increase antidiabetic doses if required.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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