Drug interactions
Saxagliptin-metformin + Sulfamethoxazole
Severity: Minor
Saxagliptin-metformin and Sulfamethoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim in co-trimoxazole inhibits renal tubular secretion of metformin, raising its levels, but sulfamethoxazole alone has little such effect. Sulfonamides may also rarely cause hypoglycemia. The interaction is generally minor.
What this interaction means in plain words
Saxagliptin-metformin and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular cationic transport (OCT2/MATE) reducing metformin clearance; sulfonamides may also enhance glucose lowering.
What to do
Monitor blood glucose and renal function if co-administered, especially with trimethoprim-containing products. Reduce the metformin dose if renal function is impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Saxagliptin-metformin with Sulfamethoxazole?
MediHelp rates the interaction as minor. Saxagliptin-metformin and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trimethoprim in co-trimoxazole inhibits renal tubular secretion of metformin, raising its levels, but sulfamethoxazole alone has little such effect. Sulfonamides may also rarely cause hypoglycemia. The interaction is generally minor.
How serious is the interaction between Saxagliptin-metformin and Sulfamethoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function if co-administered, especially with trimethoprim-containing products. Reduce the metformin dose if renal function is impaired.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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