Drug interactions
Saxagliptin-metformin + Sulfamethoxypyridazine
Severity: Minor
Saxagliptin-metformin and Sulfamethoxypyridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibiotics can enhance glucose lowering and have been linked to hypoglycemia, particularly with sulfonylureas. With metformin and saxagliptin the risk is low, but glucose-lowering may be modestly increased.
What this interaction means in plain words
Saxagliptin-metformin and Sulfamethoxypyridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism is not firmly established; sulfonamides may have additive glucose-lowering effects.
What to do
Monitor blood glucose when starting or stopping the sulfonamide, particularly in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Saxagliptin-metformin with Sulfamethoxypyridazine?
MediHelp rates the interaction as minor. Saxagliptin-metformin and Sulfamethoxypyridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfonamide antibiotics can enhance glucose lowering and have been linked to hypoglycemia, particularly with sulfonylureas. With metformin and saxagliptin the risk is low, but glucose-lowering may be modestly increased.
How serious is the interaction between Saxagliptin-metformin and Sulfamethoxypyridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the sulfonamide, particularly in patients with renal impairment.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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