Drug interactions
Saxagliptin-metformin + Tenofovir df
Severity: Moderate
Saxagliptin-metformin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil is renally eliminated and can cause kidney injury, which may reduce metformin clearance and raise the risk of lactic acidosis. Pharmacokinetic effects of tenofovir on metformin are minor, so the main concern is renal function decline.
What this interaction means in plain words
Saxagliptin-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tenofovir nephrotoxicity and possible competition for renal tubular transport may reduce metformin elimination.
What to do
Monitor renal function regularly and reduce or stop metformin if eGFR falls to unsafe levels. Counsel patients on symptoms of lactic acidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Saxagliptin-metformin and Tenofovir df, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Saxagliptin-metformin with Tenofovir df?
MediHelp rates the interaction as moderate. Saxagliptin-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir disoproxil is renally eliminated and can cause kidney injury, which may reduce metformin clearance and raise the risk of lactic acidosis. Pharmacokinetic effects of tenofovir on metformin are minor, so the main concern is renal function decline.
How serious is the interaction between Saxagliptin-metformin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function regularly and reduce or stop metformin if eGFR falls to unsafe levels. Counsel patients on symptoms of lactic acidosis.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
