Drug interactions
Scopolamine + Tolterodine
Severity: Moderate
Scopolamine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic agents, so combining them increases dry mouth, constipation, urinary retention, blurred vision and CNS effects such as confusion. Older adults are at the highest risk of delirium and falls.
What this interaction means in plain words
Scopolamine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Scopolamine belongs to Respiratory; Tolterodine belongs to Genitourinary.
Why it happens
Additive muscarinic receptor blockade.
What to do
Avoid combining where possible, especially in older patients. Otherwise monitor for anticholinergic toxicity and reduce the dose if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Tolterodine
Frequently asked questions
Can I take Scopolamine with Tolterodine?
MediHelp rates the interaction as moderate. Scopolamine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic agents, so combining them increases dry mouth, constipation, urinary retention, blurred vision and CNS effects such as confusion. Older adults are at the highest risk of delirium and falls.
How serious is the interaction between Scopolamine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, especially in older patients. Otherwise monitor for anticholinergic toxicity and reduce the dose if it occurs.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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