Drug interactions
Scopolamine + Trospium
Severity: Moderate
Scopolamine and Trospium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scopolamine is a potent antimuscarinic with central effects, so it adds to the peripheral antimuscarinic effects of trospium. Dry mouth, constipation, urinary retention, blurred vision, drowsiness and confusion may be more pronounced, particularly in older adults.
What this interaction means in plain words
Scopolamine and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Scopolamine belongs to Respiratory; Trospium belongs to Genitourinary.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic adverse effects and confusion, and avoid in frail or elderly patients when possible. Consider a non-anticholinergic antiemetic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trospium
- Clozapine + Trospium Major
- Pramlintide + Trospium Major
- Thioridazine + Trospium Major
- Trihexyphenidyl + Trospium Major
- Aclidinium + Trospium Moderate
- Amantadine + Trospium Moderate
Other interactions of Scopolamine
Frequently asked questions
Can I take Scopolamine with Trospium?
MediHelp rates the interaction as moderate. Scopolamine and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Scopolamine is a potent antimuscarinic with central effects, so it adds to the peripheral antimuscarinic effects of trospium. Dry mouth, constipation, urinary retention, blurred vision, drowsiness and confusion may be more pronounced, particularly in older adults.
How serious is the interaction between Scopolamine and Trospium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and confusion, and avoid in frail or elderly patients when possible. Consider a non-anticholinergic antiemetic.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
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