Drug interactions
Scullcap + Ziprasidone
Severity: Minor
Scullcap and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap is a herbal product with traditional sedative properties, so it may add to the drowsiness caused by ziprasidone. Data are limited and product content varies.
What this interaction means in plain words
Scullcap and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive CNS depression; the herb's effects on GABA-ergic activity are not well established.
What to do
Ask patients about herbal supplement use and advise them to report excessive drowsiness. Consider stopping the herb if sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Scullcap with Ziprasidone?
MediHelp rates the interaction as minor. Scullcap and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap is a herbal product with traditional sedative properties, so it may add to the drowsiness caused by ziprasidone. Data are limited and product content varies.
How serious is the interaction between Scullcap and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal supplement use and advise them to report excessive drowsiness. Consider stopping the herb if sedation is troublesome.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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