Drug interactions
Secobarbital + Teniposide
Severity: Major
Secobarbital and Teniposide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce enzymes that clear teniposide, and enhanced clearance of teniposide has been seen with enzyme-inducing anticonvulsants. Lower exposure may reduce chemotherapy efficacy.
What this interaction means in plain words
Secobarbital and Teniposide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Barbiturate induction of CYP3A4 increases teniposide metabolism.
What to do
Avoid the combination if possible and use a non-inducing sedative. If inducers are unavoidable, monitor the oncologic response and toxicity closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Secobarbital with Teniposide?
MediHelp rates the interaction as major. Secobarbital and Teniposide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates induce enzymes that clear teniposide, and enhanced clearance of teniposide has been seen with enzyme-inducing anticonvulsants. Lower exposure may reduce chemotherapy efficacy.
How serious is the interaction between Secobarbital and Teniposide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use a non-inducing sedative. If inducers are unavoidable, monitor the oncologic response and toxicity closely.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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