Drug interactions
Secobarbital + Tezacaftor
Severity: Major
Secobarbital and Tezacaftor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may induce CYP3A4 and decrease tezacaftor levels. This may reduce the benefit of cystic fibrosis modulator therapy.
What this interaction means in plain words
Secobarbital and Tezacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Barbiturate induction of CYP3A4 increases tezacaftor metabolism.
What to do
Avoid concomitant strong CYP3A4 inducers; labeling does not recommend the combination. Use an alternative hypnotic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Secobarbital with Tezacaftor?
MediHelp rates the interaction as major. Secobarbital and Tezacaftor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital may induce CYP3A4 and decrease tezacaftor levels. This may reduce the benefit of cystic fibrosis modulator therapy.
How serious is the interaction between Secobarbital and Tezacaftor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant strong CYP3A4 inducers; labeling does not recommend the combination. Use an alternative hypnotic.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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