Drug interactions
Secobarbital + Thalidomide
Severity: Moderate
Secobarbital and Thalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thalidomide has sedative properties and can add to the central nervous system depression caused by barbiturates. This may cause excessive drowsiness, confusion and impaired alertness.
What this interaction means in plain words
Secobarbital and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Secobarbital belongs to Central Nervous System; Thalidomide belongs to Miscellaneous.
Why it happens
Additive sedative effects; the exact mechanism of thalidomide's sedation is not well established.
What to do
Monitor for excessive sedation and consider dose reduction of either agent. Advise patients to avoid driving and hazardous tasks, and to take thalidomide in the evening.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Thalidomide
Frequently asked questions
Can I take Secobarbital with Thalidomide?
MediHelp rates the interaction as moderate. Secobarbital and Thalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thalidomide has sedative properties and can add to the central nervous system depression caused by barbiturates. This may cause excessive drowsiness, confusion and impaired alertness.
How serious is the interaction between Secobarbital and Thalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider dose reduction of either agent. Advise patients to avoid driving and hazardous tasks, and to take thalidomide in the evening.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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