Drug interactions
Secobarbital + Thiothixene
Severity: Moderate
Secobarbital and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause marked sedation, hypotension and impaired psychomotor function. Antipsychotics may also lower the seizure threshold, adding complexity in some patients.
What this interaction means in plain words
Secobarbital and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABAergic potentiation by the barbiturate and antihistaminic, anti-adrenergic and dopamine-blocking effects of the antipsychotic.
What to do
Monitor sedation level and blood pressure, particularly when starting or increasing either drug. Reduce doses if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Secobarbital with Thiothixene?
MediHelp rates the interaction as moderate. Secobarbital and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause marked sedation, hypotension and impaired psychomotor function. Antipsychotics may also lower the seizure threshold, adding complexity in some patients.
How serious is the interaction between Secobarbital and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and blood pressure, particularly when starting or increasing either drug. Reduce doses if excessive drowsiness occurs.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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