Drug interactions
Secobarbital + Thyroid desiccated
Severity: Moderate
Secobarbital and Thyroid desiccated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can speed the clearance of thyroid hormones. In patients on replacement therapy this may lead to reduced effect and rising TSH.
What this interaction means in plain words
Secobarbital and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzyme induction increases hepatic metabolism of thyroxine and triiodothyronine.
What to do
Check TSH and thyroid status several weeks after starting or stopping secobarbital and adjust the thyroid dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Secobarbital with Thyroid desiccated?
MediHelp rates the interaction as moderate. Secobarbital and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and can speed the clearance of thyroid hormones. In patients on replacement therapy this may lead to reduced effect and rising TSH.
How serious is the interaction between Secobarbital and Thyroid desiccated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH and thyroid status several weeks after starting or stopping secobarbital and adjust the thyroid dose as required.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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