Drug interactions
Secobarbital + Topiramate
Severity: Moderate
Secobarbital and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and cognitive slowing, so combining them can increase drowsiness, confusion and psychomotor impairment. The effect is usually manageable but affects driving and daily function.
What this interaction means in plain words
Secobarbital and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Secobarbital belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depression via barbiturate GABA-A enhancement and topiramate's GABAergic and sodium-channel effects.
What to do
Monitor for excessive sedation and cognitive impairment and titrate doses slowly. Advise patients to avoid driving and alcohol until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Topiramate
Frequently asked questions
Can I take Secobarbital with Topiramate?
MediHelp rates the interaction as moderate. Secobarbital and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and cognitive slowing, so combining them can increase drowsiness, confusion and psychomotor impairment. The effect is usually manageable but affects driving and daily function.
How serious is the interaction between Secobarbital and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and cognitive impairment and titrate doses slowly. Advise patients to avoid driving and alcohol until the response is known.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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