Drug interactions
Secobarbital + Trifluoperazine
Severity: Moderate
Secobarbital and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together these drugs can cause additive sedation, hypotension and psychomotor impairment. Phenothiazines may also lower seizure threshold, and barbiturates can alter phenothiazine levels through enzyme induction.
What this interaction means in plain words
Secobarbital and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible barbiturate induction of hepatic metabolism of the antipsychotic.
What to do
Monitor sedation, blood pressure and psychiatric response, and adjust doses if oversedation or loss of antipsychotic effect occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Secobarbital with Trifluoperazine?
MediHelp rates the interaction as moderate. Secobarbital and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together these drugs can cause additive sedation, hypotension and psychomotor impairment. Phenothiazines may also lower seizure threshold, and barbiturates can alter phenothiazine levels through enzyme induction.
How serious is the interaction between Secobarbital and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and psychiatric response, and adjust doses if oversedation or loss of antipsychotic effect occurs.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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