Drug interactions
Secobarbital + Triprolidine
Severity: Major
Secobarbital and Triprolidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a barbiturate with a sedating antihistamine produces greater CNS depression, with marked drowsiness and, at higher doses, risk of respiratory depression. Impaired coordination and judgment are likely.
What this interaction means in plain words
Secobarbital and Triprolidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Secobarbital belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression from barbiturate GABA-A potentiation and antihistaminic sedation.
What to do
Avoid the combination where possible, or use reduced doses with monitoring of sedation and respiration. Choose a non-sedating antihistamine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Triprolidine
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Secobarbital with Triprolidine?
MediHelp rates the interaction as major. Secobarbital and Triprolidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a barbiturate with a sedating antihistamine produces greater CNS depression, with marked drowsiness and, at higher doses, risk of respiratory depression. Impaired coordination and judgment are likely.
How serious is the interaction between Secobarbital and Triprolidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use reduced doses with monitoring of sedation and respiration. Choose a non-sedating antihistamine.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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