Drug interactions
Secobarbital + Vorapaxar
Severity: Moderate
Secobarbital and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may induce CYP3A4 and lower vorapaxar concentrations, potentially reducing antiplatelet effect. The clinical consequence would be a diminished protection against thrombotic events.
What this interaction means in plain words
Secobarbital and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4-mediated vorapaxar metabolism by the barbiturate.
What to do
Consider a non-inducing alternative to secobarbital; if coadministered, monitor for signs of reduced antiplatelet efficacy and thrombotic events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Secobarbital with Vorapaxar?
MediHelp rates the interaction as moderate. Secobarbital and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may induce CYP3A4 and lower vorapaxar concentrations, potentially reducing antiplatelet effect. The clinical consequence would be a diminished protection against thrombotic events.
How serious is the interaction between Secobarbital and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-inducing alternative to secobarbital; if coadministered, monitor for signs of reduced antiplatelet efficacy and thrombotic events.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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