Drug interactions
Segesterone / ethinyl estradiol + Warfarin
Severity: Moderate
Segesterone / ethinyl estradiol and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing contraceptives raise levels of several clotting factors and can reduce warfarin's anticoagulant effect, though changes in INR in either direction have been reported. They also increase thrombotic risk independently, which is important in patients needing anticoagulation.
What this interaction means in plain words
Segesterone / ethinyl estradiol and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Estrogen increases hepatic synthesis of clotting factors, opposing warfarin pharmacodynamically; effects on warfarin metabolism are inconsistent.
What to do
Monitor INR when the contraceptive is started or stopped and adjust the warfarin dose accordingly. Consider a non-estrogen contraceptive in patients with thrombotic disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Segesterone / ethinyl estradiol with Warfarin?
MediHelp rates the interaction as moderate. Segesterone / ethinyl estradiol and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estrogen-containing contraceptives raise levels of several clotting factors and can reduce warfarin's anticoagulant effect, though changes in INR in either direction have been reported. They also increase thrombotic risk independently, which is important in patients needing anticoagulation.
How serious is the interaction between Segesterone / ethinyl estradiol and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR when the contraceptive is started or stopped and adjust the warfarin dose accordingly. Consider a non-estrogen contraceptive in patients with thrombotic disease.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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