Drug interactions
Selegiline + Zuranolone
Severity: Moderate
Selegiline and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and impaired psychomotor performance, and other CNS-active drugs may add to these effects. Selegiline may contribute modest additive sedation or dizziness, though the interaction is not well studied.
What this interaction means in plain words
Selegiline and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selegiline belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through pharmacodynamic synergy.
What to do
Counsel patients about drowsiness and driving impairment, and consider reducing the zuranolone dose if excess sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Selegiline with Zuranolone?
MediHelp rates the interaction as moderate. Selegiline and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and impaired psychomotor performance, and other CNS-active drugs may add to these effects. Selegiline may contribute modest additive sedation or dizziness, though the interaction is not well studied.
How serious is the interaction between Selegiline and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and driving impairment, and consider reducing the zuranolone dose if excess sedation occurs.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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