Drug interactions
Selegiline transdermal + Tolazamide
Severity: Moderate
Selegiline transdermal and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors have been reported to enhance the glucose-lowering effect of antidiabetic drugs, so tolazamide may cause more hypoglycemia. Transdermal selegiline at antidepressant doses gives limited MAO-B selectivity, so the effect is plausible but poorly documented.
What this interaction means in plain words
Selegiline transdermal and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition may enhance insulin secretion or sensitivity and potentiate sulfonylurea action; the mechanism is not firmly established.
What to do
Monitor blood glucose when selegiline is started or stopped. Reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Selegiline transdermal with Tolazamide?
MediHelp rates the interaction as moderate. Selegiline transdermal and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors have been reported to enhance the glucose-lowering effect of antidiabetic drugs, so tolazamide may cause more hypoglycemia. Transdermal selegiline at antidepressant doses gives limited MAO-B selectivity, so the effect is plausible but poorly documented.
How serious is the interaction between Selegiline transdermal and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when selegiline is started or stopped. Reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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