Drug interactions
Selegiline transdermal + Tolbutamide
Severity: Minor
Selegiline transdermal and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors have been reported to enhance the hypoglycemic effect of antidiabetic drugs. With transdermal selegiline at antidepressant doses, this is a possible but weakly documented effect.
What this interaction means in plain words
Selegiline transdermal and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism not established; MAO inhibition may influence glucose regulation.
What to do
Monitor blood glucose when starting or stopping selegiline and adjust tolbutamide if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Selegiline transdermal with Tolbutamide?
MediHelp rates the interaction as minor. Selegiline transdermal and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. MAO inhibitors have been reported to enhance the hypoglycemic effect of antidiabetic drugs. With transdermal selegiline at antidepressant doses, this is a possible but weakly documented effect.
How serious is the interaction between Selegiline transdermal and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping selegiline and adjust tolbutamide if hypoglycemia occurs.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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