Drug interactions
Selegiline transdermal + Tranylcypromine
Severity: Contraindicated
Selegiline transdermal and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs inhibit MAO, and transdermal selegiline at antidepressant doses inhibits both isoforms. Together they increase the risk of serotonin syndrome and hypertensive crisis. Labeling contraindicates the combination.
What this interaction means in plain words
Selegiline transdermal and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Duplicate irreversible MAO inhibition causes additive accumulation of serotonin and catecholamines.
What to do
Do not co-administer. Allow at least 14 days between stopping one MAOI and starting the other.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Selegiline transdermal with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Selegiline transdermal and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs inhibit MAO, and transdermal selegiline at antidepressant doses inhibits both isoforms. Together they increase the risk of serotonin syndrome and hypertensive crisis. Labeling contraindicates the combination.
How serious is the interaction between Selegiline transdermal and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days between stopping one MAOI and starting the other.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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