Drug interactions
Selpercatinib + Sunitinib
Severity: Moderate
Selpercatinib and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. Selpercatinib is also a CYP3A4 substrate and weak inhibitor, which may add to exposure effects.
What this interaction means in plain words
Selpercatinib and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selpercatinib belongs to Oncology; Sunitinib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Obtain baseline and periodic ECGs and monitor electrolytes, correcting abnormalities. Dose-interrupt or reduce if QTc increases markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Selpercatinib
Frequently asked questions
Can I take Selpercatinib with Sunitinib?
MediHelp rates the interaction as moderate. Selpercatinib and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. Selpercatinib is also a CYP3A4 substrate and weak inhibitor, which may add to exposure effects.
How serious is the interaction between Selpercatinib and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and monitor electrolytes, correcting abnormalities. Dose-interrupt or reduce if QTc increases markedly.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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