Drug interactions
Selpercatinib + Telavancin
Severity: Moderate
Selpercatinib and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib and telavancin each can prolong the QT interval, so combining them may raise the risk of serious ventricular arrhythmia. Patients with cardiac disease or electrolyte abnormalities are at the greatest risk.
What this interaction means in plain words
Selpercatinib and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selpercatinib belongs to Oncology; Telavancin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Check ECG and electrolytes at baseline and periodically during co-treatment. Replace potassium and magnesium as needed and reassess therapy if the QTc rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Selpercatinib
Frequently asked questions
Can I take Selpercatinib with Telavancin?
MediHelp rates the interaction as moderate. Selpercatinib and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib and telavancin each can prolong the QT interval, so combining them may raise the risk of serious ventricular arrhythmia. Patients with cardiac disease or electrolyte abnormalities are at the greatest risk.
How serious is the interaction between Selpercatinib and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and periodically during co-treatment. Replace potassium and magnesium as needed and reassess therapy if the QTc rises significantly.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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