Drug interactions
Selumetinib + Sertraline
Severity: Minor
Selumetinib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selumetinib is metabolized mainly by CYP3A4, and sertraline is only a weak inhibitor of this enzyme. A clinically meaningful rise in selumetinib exposure is unlikely, unlike with moderate or strong inhibitors.
What this interaction means in plain words
Selumetinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Selumetinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline may slightly raise selumetinib concentrations.
What to do
No empiric selumetinib dose reduction is needed. Monitor for selumetinib toxicity such as gastrointestinal effects, rash and reduced ejection fraction as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Selumetinib
Frequently asked questions
Can I take Selumetinib with Sertraline?
MediHelp rates the interaction as minor. Selumetinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Selumetinib is metabolized mainly by CYP3A4, and sertraline is only a weak inhibitor of this enzyme. A clinically meaningful rise in selumetinib exposure is unlikely, unlike with moderate or strong inhibitors.
How serious is the interaction between Selumetinib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric selumetinib dose reduction is needed. Monitor for selumetinib toxicity such as gastrointestinal effects, rash and reduced ejection fraction as usual.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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