Drug interactions
Selumetinib + Ticagrelor
Severity: Moderate
Selumetinib and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selumetinib carries a bleeding warning and contains vitamin E, which has antiplatelet effects. With ticagrelor, bleeding risk may increase.
What this interaction means in plain words
Selumetinib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selumetinib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Additive effects on hemostasis; selumetinib capsules contain vitamin E, which impairs platelet function.
What to do
Monitor for bleeding signs and review the need for combined therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Selumetinib
Frequently asked questions
Can I take Selumetinib with Ticagrelor?
MediHelp rates the interaction as moderate. Selumetinib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selumetinib carries a bleeding warning and contains vitamin E, which has antiplatelet effects. With ticagrelor, bleeding risk may increase.
How serious is the interaction between Selumetinib and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and review the need for combined therapy.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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