Drug interactions
Serdexmethylphenidate / dexmethylphenidate + Tranylcypromine
Severity: Contraindicated
Serdexmethylphenidate / dexmethylphenidate and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylphenidate-type stimulants given with a nonselective MAO inhibitor can cause hypertensive crisis. Labeling contraindicates use during or within 14 days of MAOI therapy.
What this interaction means in plain words
Serdexmethylphenidate / dexmethylphenidate and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Stimulant-induced catecholamine release combined with blocked catecholamine breakdown by MAO inhibition.
What to do
Do not co-administer. Wait at least 14 days after stopping tranylcypromine before starting this stimulant.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Serdexmethylphenidate / dexmethylphenidate with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Serdexmethylphenidate / dexmethylphenidate and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylphenidate-type stimulants given with a nonselective MAO inhibitor can cause hypertensive crisis. Labeling contraindicates use during or within 14 days of MAOI therapy.
How serious is the interaction between Serdexmethylphenidate / dexmethylphenidate and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Wait at least 14 days after stopping tranylcypromine before starting this stimulant.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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