Drug interactions
Sertraline + Sulfasalazine
Severity: Minor
Sertraline and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The legacy concern is bleeding, but sulfasalazine is not a typical antiplatelet NSAID and has little direct effect on platelet function. Any added bleeding risk is small, although sulfasalazine can cause blood dyscrasias.
What this interaction means in plain words
Sertraline and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No well-established mechanism; a minor additive effect on bleeding is theoretical.
What to do
No routine action is needed. Monitor blood counts as usual for sulfasalazine and evaluate unexplained bleeding or bruising.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Sertraline with Sulfasalazine?
MediHelp rates the interaction as minor. Sertraline and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The legacy concern is bleeding, but sulfasalazine is not a typical antiplatelet NSAID and has little direct effect on platelet function. Any added bleeding risk is small, although sulfasalazine can cause blood dyscrasias.
How serious is the interaction between Sertraline and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Monitor blood counts as usual for sulfasalazine and evaluate unexplained bleeding or bruising.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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